I am interested in the biochemistry and biophysics of membrane proteins, and my research involves structural determination and dynamic studies of ion channels and receptors that are essential to sensory signal transduction. One family of ion channel proteins that are of particular interest are the transient potential receptor (TRP) channels, generally described as the vanguard of our sensory systems that are involved in temperature sensing, taste, olfaction, chemosensation, and mechanosensation. My lab is trying to elucidate the atomic details of the channel proteins and their corresponding activation and regulation mechanism, especially their interactions with membrane-bound second messenger, both structurally and dynamically, using novel nuclear magnetic resonance (NMR) spectroscopic methods, combining with other cutting-edge spectroscopic and thermodynamic techniques (fluorescence, CD, FTIR, ITC, DSC, SPR, etc.) and computational approaches.
- Ph.D., Columbia University, New York, NY 1999
- M.A., Columbia University, New York, NY 1995
- B.S., Peking University, Beijing, China, 1994
- "A TAF4-homology domain from the corepressor ETO is a docking platform for positive and negative regulators of transcription", Nature Structural and Molecular Biology, 14, 653- 661, June 2007
- "iDC: A Comprehensive Toolkit for the Analysis of Residual Dipolar Couplings for Macromolecular Structure Determination", J. Biomol. NMR, 35(1), 17- 25, May 2006
- "PISEMA Solid-State NMR Spectroscopy", Annual Reports on NMR Spectroscopy, 52, Academic Press Ltd, 1- 52, April 2004
- "Recovery of Dipolar and Chemical Shift Anisotropic Interactions and Sideband Enhancement under Magic Angle Spinning", J. Magn. Reson, 158, 23- 35, April 2002
"One-Dimensional 1H-Detected Solid-State NMR Experiment to Determine Amide-1H Chemical Shifts in Peptides"
Chemical Physics Letters, 351(1-2), 42- 46, January 2002
- University Research Council Award, 2008, Seton Hall University