Academic Scholarship

Interplay of Sps and Poly C binding protein 1 on the mu-opioid receptor gene expression

Biochem. Biophys. Res. Comm., 345, 530- 537, June 2006

Photo Needed Jane L. Ko, Ph.D.
Department of Biological Sciences
A. Rivera-Gines, R.J. Cook and H.H. Loh

The proximal promoter of mouse mu-opioid receptor (MOR) gene is the dominant promoter for directing MOR-1 gene expression in brain. Sp1/Sp3 (Sps) and poly(C) binding protein 1 (PCBP) bind to a cis-element of MOR proximal promoter. Functional interaction between Sps and PCBP and their individual roles on MOR proximal core promoter were investigated using SL2 cells, devoid of Sps and PCBP.


Sign In to PirateNet