Two of Seton Hall's most important research assets will be on display in a June edition of the important general interest journal Chemical Communications, published by the Royal Society of Chemistry. In each edition of this journal, one article is selected for special attention on the journal cover, and faculty authors Sergiu Gorun and David Sabatino of the Department of Chemistry and Biochemistry were given the coveted spot. The authors chose to display the compound at the center of their research over the backdrop of the Science Building's beloved "Atom Wall," the now aesthetic centerpiece of the state of the art facility which previously served as the exterior face of the old McNulty Hall.
Even more important than the historic architecture featured in this issue, Seton Hall's tradition of involving undergraduate and graduate students in cutting-edge research played an important part in this report. Graduate students Pradeepkumar Patel and Hemantbhai Patel, as well as undergraduate student Emily Borland, were part of the research team on the report titled "Chemically robust fluoroalkyl phthalocyanine–oligonucleotide bioconjugates and their GRP78 oncogene photocleavage activity."
According to the study's authors, the method described in the journal article could mitigate the side-effects from cancer treatment that other commonly used methods such as chemotherapy and radiation are known to create. The researchers explained, "This cancer-targeting strategy combines the anti-cancer effects of a fluorinated phthalocyanine photosensitizer, with an oligonucleotide that binds selectively to an oncogene (i.e. DNA or mRNA) responsible for tumor production. The photosensitizer has the ability to harvest light energy and convert atmospheric oxygen into a form of reactive oxygen species (singlet oxygen), which aberrantly modifies the oncogene, rendering it susceptible towards degradation resulting in potent anti-cancer effects." This new research will lead to cancer-fighting treatments that are more selective in terms of eradicating the cancer itself, and less of the healthy tissue, thereby generating fewer side effects than traditional treatments.
This communication will appear in Volume 50, Number 48, pgs. 6287-6410 of Chemical Communications. The issue is set to be published on June 18, 2014.
Chemical Communications has been published by the Royal Society of Chemistry since 1989. The journal is popular amongst academic and industrial chemists in all areas of the chemical sciences. ChemComm publishes 100 issues per year, which include short communications and feature articles, reviews written by leading scientists summarizing recent work within their field from a personal perspective. The journal is known for being the fastest publisher of articles due to their weekly publishing. ChemComm currently has a 6.378 impact factor, and has been cited in databases including MEDLINE, Methods in Organic Synthesis, and Natural Product Updates.
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