The Rose Mercadante Chemistry and Biochemistry Seminar Series is pleased to present a seminar by Professor Zhang Wang of SUNY-Albany entitled "Total Syntheses of Nannocystins and Biomimetic Syntheses of Natural Products."
The seminar will be held on from 5:45 to 7 p.m. on Tuesday, April 17, 2018 in the Helen Lerner Amphitheater, Science and Technology Center. Refreshments are available at 5:30 p.m.
Zhang Wang received his B.S. degree in chemistry from Peking University in 2005, supervised by Professor Jiaxi Xu. After one year of post-undergraduate research on DNA hybridization with Professor Xin Sheng Zhao at Peking University, he started his graduate training under Professor Samuel J. Danishefsky at Columbia University, working on the total synthesis of natural products. He then moved to Princeton University to conduct postdoctoral research in Professor David MacMillan's group, before joining SUNY-Albany in summer 2014. His current research interest includes methodology development and total synthesis of natural products.
Natural products have served as a main source of current drugs due to their structural diversity. About one half of current small-molecule drugs on the market are natural products or their synthetic analogs. Natural product synthesis has benefited drug discovery by providing a supply alternative to the natural source, and by making more active analogs. The first section of this talk centers on the total syntheses of nannocystins A and A0, two elongation factor inhibitors with nanomolar potency against 472 cancer cell lines. The second and third sections focus on our effort towards the biomimetic syntheses of natural products. Biomimetic synthesis provides experimental support on proposed biosynthetic pathways of natural products. New chemistry that was hidden in nature can be uncovered through biomimetic synthesis. The biomimetic syntheses of two families of natural products, homodimericins and hitorins, will be discussed.
The Department of Chemistry and Biochemistry offers B.S., M.S., and Ph.D. degrees with specializations in all areas of chemistry. Our unique research environment, including traditional full-time students and part-time students is designed to foster collaborations with industry and colleagues in other disciplines. The Rose Mercadante Seminar Series is named for Rose Mercadante, the departmental secretary for over 40 years, in honor of our alumni, her "boys and girls."