Somatostatin: A hormone for the heart?
Current Vascular Pharmacology, 3(2), 125- 131, April 2005
Allan D. Blake, Ph.D.
Department of Biological Studies
Somatostatin (somatotropin release inhibitory factor; SRIF) peptides are widely distributed throughout the mammalian body and act through a family of genetically distinct, guanine nucleotide regulatory protein coupled (G-protein-coupled), cell surface receptors (sst(1-5)). A detailed understanding of SRIF actions could provide a rational basis for using SRIF ligands in controlling vascular inflammation and inhibiting cytokine signaling, critical events in atherogenesis.