Somatostatin increases voltage-gated K+ currents in GH3 cells through the activation of multiple somatostatin receptors
Endocrinology, 146(11), 4975- 4984, August 2005
Allan D. Blake, Ph.D.
Department of Biological Studies
S-K. Yang, H.C. Parkington, D.J. Keating and C. Chen
The secretion of GH by somatotropes is inhibited by somatostatin (SRIF) through five specific membrane receptors (SSTRs). SRIF increases both transient outward (IA) and delayed rectifying (IK) K+ currents. We aim to clarify the subtype(s) of SSTRs involved in K+ current enhancement in GH3 somatotrope cells using specific SSTR subtype agonists. Expression of all five SSTRs was confirmed in GH3 cells by RT-PCR.