Interplay of Sps and Poly C binding protein 1 on the mu-opioid receptor gene expression
Biochem. Biophys. Res. Comm., 345, 530- 537, June 2006
Jane L. Ko, Ph.D.
Department of Biological Sciences
A. Rivera-Gines, R.J. Cook and H.H. Loh
The proximal promoter of mouse mu-opioid receptor (MOR) gene is the dominant promoter for directing MOR-1 gene expression in brain. Sp1/Sp3 (Sps) and poly(C) binding protein 1 (PCBP) bind to a cis-element of MOR proximal promoter. Functional interaction between Sps and PCBP and their individual roles on MOR proximal core promoter were investigated using SL2 cells, devoid of Sps and PCBP.