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Blockage of the Glucocorticoid but not the Mineralocorticoid receptor prevents the delayed persistent increase in circulating basal corticosterone concentration following stress in the rat

Neuroscience letters, 374, 25- 28, February 2005

Photo Needed Roberta L. Moldow, Ph.D.
Department of Biological Sciences
K. D. Beck, S. A. Weaver and R. J. Servatius

Exposure to a single session of intense inescapable stressors results in elevations of plasma corticosterone levels selective to the trough of the circadian rhythm that last for several days after stressor cessation. In the present study, we examined whether this stress-induced alteration in the regulation of the circadian trough is dependent upon glucocorticoid and/or mineralocorticoid receptor activation during stress.


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