Blockage of the Glucocorticoid but not the Mineralocorticoid receptor prevents the delayed persistent increase in circulating basal corticosterone concentration following stress in the rat
Neuroscience letters, 374, 25- 28, February 2005
Roberta L. Moldow, Ph.D.
Department of Biological Studies
K. D. Beck, S. A. Weaver and R. J. Servatius
Exposure to a single session of intense inescapable stressors results in elevations of plasma corticosterone levels selective to the trough of the circadian rhythm that last for several days after stressor cessation. In the present study, we examined whether this stress-induced alteration in the regulation of the circadian trough is dependent upon glucocorticoid and/or mineralocorticoid receptor activation during stress.