HPLC with Charged Aerosol Detection for Pharmaceutical Cleaning Validation
LCGC North America, 25(9), 960- 968, September 2007
Nicholas H. Snow, Ph.D.
Department of Chemistry and Biochemistry
In this work, several traditional cleaning solvents for manufacturing devices spiked with typical drug substances and impurities were examined. Forsatz and Snow demonstrate quantitation of the drug substance and will examine the potential of CAD detection for non-chromophore impurities, giving a more accurate picture of contaminants remaining on the equipment.