Nuclear translocation of phospholipase C-delta 1 is linked to the cell cycle and nuclear phosphatidylinositol 4,5- bisphosphate
Journal of Biological Chemistry, 280(23), 22060- 22069, June 2005
Edward G. Tall, Ph.D.
Department of Biological Sciences
J.D. Stallings, S. Pentyala and M.J. Rebecchi
Nuclear phosphoinositides, especially phosphatidylinositol 4,5-bisphosphate, fluctuate throughout the cell cycle and are linked to proliferation and differentiation. Here we report that phospholipase C-delta(1) accumulates in the nucleus at the G(1)/S boundary and in G(0) phases of the cell cycle.