Academic Scholarship

Nuclear translocation of phospholipase C-delta 1 is linked to the cell cycle and nuclear phosphatidylinositol 4,5- bisphosphate

Journal of Biological Chemistry, 280(23), 22060- 22069, June 2005

Photo Needed Edward G. Tall, Ph.D.
Department of Biological Studies
J.D. Stallings, S. Pentyala and M.J. Rebecchi

Nuclear phosphoinositides, especially phosphatidylinositol 4,5-bisphosphate, fluctuate throughout the cell cycle and are linked to proliferation and differentiation. Here we report that phospholipase C-delta(1) accumulates in the nucleus at the G(1)/S boundary and in G(0) phases of the cell cycle.

 
 

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