Methamphetamine-Induced Behavioral Sensitization is Enhanced in the HIV-1 Transgenic Rat
Journal of Neuroimmune Pharmacology, May 2009
Michael Vigorito, Ph.D.
Department of Psychology
X. Liu, L. Chang, M. Kass, H. Li & S.L. Chang
Methamphetamine (METH) addiction is prevalent among individuals with HIV infection. We hypothesize that HIV-positive individuals are more prone to METH use and to the development of METH dependence. To test this hypothesis, we examined the effects of METH (daily intraperitoneal injection 2.5 mg/kg for 6 days) on rearing and head movement in 12-13-week-old male HIV-1 transgenic (HIV-1Tg) rats compared to F344 control rats as an indicator of behavioral sensitization, also representing neural adaptation underlying drug dependence and addiction.