Academic Scholarship

Methamphetamine-Induced Behavioral Sensitization is Enhanced in the HIV-1 Transgenic Rat

Journal of Neuroimmune Pharmacology, May 2009

Photo Needed Michael Vigorito, Ph.D.
Department of Psychology
X. Liu, L. Chang, M. Kass, H. Li & S.L. Chang

Methamphetamine (METH) addiction is prevalent among individuals with HIV infection. We hypothesize that HIV-positive individuals are more prone to METH use and to the development of METH dependence. To test this hypothesis, we examined the effects of METH (daily intraperitoneal injection 2.5 mg/kg for 6 days) on rearing and head movement in 12-13-week-old male HIV-1 transgenic (HIV-1Tg) rats compared to F344 control rats as an indicator of behavioral sensitization, also representing neural adaptation underlying drug dependence and addiction.


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